Effect of ultraviolet‐B irradiation on antioxidative properties of aqueous extracts from shiitake (Lentinus edodes) mushrooms

Antioxidant properties of aqueous extracts from Lentinus edodes treated with UV‐B irradiation were examined in vitro systems including DPPH, ABTS and oxygen radical absorbance capacity (ORAC) assays and in riboflavin‐photosensitised oil‐in‐water (O/W) emulsions. Changes in total phenolics, total flavonoids and vitamin C were also analysed. Lentinus edodes receiving 25 kJ m^?2 UV‐B treatment showed high radical scavenging ability based on DPPH and ABTS assays compared with samples with 0, 50 and 75 kJ m^?2, while those with 50 kJ m^?2 had higher antioxidant capacities than other samples from ORAC assays. Samples with 25 kJ m^?2 UV treatment had significantly 7.1% higher total phenolic content, 12.0% higher total flavonoid content and 8.0% higher vitamin C content than UV‐B‐untreated sample (P < 0.05), respectively. In O/W emulsions under riboflavin photosensitisation, 25 and 50 kJ m^?2 UV treatment significantly increased the oxidative stability compared with other samples based on headspace oxygen content and lipid hydroperoxide analyses (P < 0.05). Aqueous extracts of UV‐B‐treated mushrooms possessed enhanced antioxidant properties compared with untreated mushrooms.     

‘s Gravesande's Appropriation of Newton's Natural Philosophy,Part II: Methodological Issues

It has been suggested in the literature that, although Willem Jacob ‘s Gravesande occasionally treated Newton's doctrines in a selective manner, he was nevertheless an unremitting follower of Newton's methodology. As part of a reassessment of ‘s Gravesande's Newtonianism, I argue that, although ‘s Gravesande took over key terms of Newton's methodological canon, his methodological ideas are upon close scrutiny quite different from and occasionally even incongruent with Newton's views on the matter.     

Thermodynamic investigation of phase equilibria on the (W,Mo)C-(Co,Ni) cemented carbides

The C-Co-Mo-W and C-Mo-Ni-W quaternary systems have been critically evaluated by means of the CALPHAD approach, in which the Co-Mo-W system was readjusted to ensure the model consistency. The thermodynamic models of Gibbs energies for individual phases in the ternary and quaternary systems are described, including substitutional solution model, sublattice model and linear compound model. The modeling covers the whole temperature and composition ranges, and a set of self-consistent thermodynamic parameters for the C-Co-Mo-W and C-Mo-Ni-W quaternary systems is obtained. According to the comprehensive comparisons between the reported and calculated phase diagram data, the reliable equilibria information is satisfactorily accounted for by the modeling. Based on the present work together with the previously reported assessments of binary, ternary and quaternary sub-systems, a thermodynamic database for the C-Co-Mo-Ni-W quinary system is constructed and applied to calculate the sintering region phase equilibria of the (W,Mo)C-(Co,Ni) cemented carbides.     

吐哈盆地葡北地区“两宽一高”地震勘探技术及应用效果

吐哈盆地台北凹陷圈闭落实的准确度和储层分布预测的精度一直是制约该区油气发现的关键因素。通过可控震源“两宽一高”地震采集、OVT域时间偏移、地质导向深度偏移初始模型建立及各向异性深度偏移迭代处理，在地震资料的信噪比、频带宽度和分辨率等方面明显提高的基础上，以高精度层序地层学为指导，基于高分辨率地震资料与钻井、测井资料的综合分析，识别出侏罗系6个三级层序，在三级层序格架内将研究区七克台组底部和三间房组顶部砂体识别为两个连续上升半旋回四级层序；通过构造几何属性分析及精细构造分析，揭示了本区“四带、两凹”的构造格局及形成机制；以宽频带多种反演技术为手段，对含油气层段的七克台组和三间房组砂体分布进行了预测；在综合构造分析、储层分析和油藏成藏规律分析的基础上，提出本区油气沿构造带脊线聚集，断裂系统是油气运移的优势路径，七克台组、三间房组储层在葡北构造带发育，向玉果构造带和胜北次凹减薄尖灭，葡北构造带与玉果构造带结合部位的，具有鼻状构造背景的岩性圈闭是获得油气突破的有利地区。     

一种基于5W1H的数据异常访问分析研究

大数据正在改变着我们的生活，也在改变着企业的运营模式，数据已经慢慢成为企业的核心资产、战略资源。数据在被深度挖掘、共享应用的同时，也成为不法分子盗取的主要目标，因此数据安全已经成为网络安全的重要组成部分。本论文立足于数据被访问过程中可能出现的泄露场景，基于任何一次数据访问过程中的5W1H六要素，利用聚类和标签算法构建一种实时的数据异常访问综合分析方法。     

Formulation of Insulin-Loaded Polymeric Nanoparticles Using Response Surface Methodology

The objective of this work was to formulate new oral insulin-loaded nanoparticules using the response surface methodology. The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method. The polymers used for the encapsulation were blends of biodegradable poly-epsilon-caprolactone (PCL) and of positively-charged, nonbiodegradable polymer (Eudragis RS®). A central composite design has been built to investigate the effects of three controlled variables: ratio of polymers (PCL/RS ratio), volume, and pH of the aqueous solution of polyvinyl alcohol. The nanoparticles were characterized by measuring the amount of entrapped insulin, the particle size, the polydispersity of the obtained particles, the zeta potential, and the amount of insulin released after 7 hours. A second-order model was evaluated by multiple regression and was statistically tested for each of the studied controlled variable. The obtained polynomials proved efficient to localize an optimal operating area highlighted by the use of three-dimensional response surfaces and their corresponding isoresponse curves. An interesting formulation given by the models was selected, prepared, and evaluated. The corresponding quantity of entrapped insulin was 25 IU per 100 mg of polymer, and the particle size was 350 nm with a polydispersity of 0.21. The quantity of released insulin was 4.8 IU per 100 mg of polymer after 7 hours and the zeta potential was + 44 mV. All these collected values were in perfect accordance with values estimated by the models. Finally, the results suggested that PCL/RS 50/50 nanoparticles might represent a promising formulation for oral delivery of insulin.     

A Method of Estimating Variance Components in Unbalanced Designs

Another method of estimating variance components in the unbalanced case is presented for a general model with unbalanced population structure and unequal variances over the population. The method utilizes unweighted means and can be shown to give unbiased estimates when the numbers of observations are sampled and certain to be > 1. When the design is balanced the estimators coincide with the usual anova-estimators. The construction of estimators is exemplified for four situations with factors crossed and nested in different ways.     

Smart-microstructures of composites for electrical contacts with frameless packing of Cr and W in copper

W₄₅Cu₅₅, Cr₆₅Cu₃₅, and Cr₃₂W₁₄Cu₅₄ alloys were obtained in order to study the mechanism of “smart response” of the structure of these alloys when using them as arc-resistant circuit-breakers. These alloys differ from industrial ones with frameless packing of Cr and W phases in the copper matrix. The alloy production method is based on the infiltration of copper melt into a mixture of non-compacted Cr and W powders under vibration exposure (80 Hz). The research results show an increase in the arc resistance of contacts when changing from “frame” packing of W to “frameless,” as well as the decisive role of Cr in the processes of self-dispersion of arc-resistant phases and passivation of W and Cu. Based on the obtained results, conclusions are drawn about the advantage of frameless packing of arc-resistant phases in copper and the reasons for the “smart behavior” of the structure of Cr-containing contacts in response to functional loads in the presence of oxygen and an inert atmosphere.     

Influence of case-carburizing and micro-defect on competing failure behaviors of Ni–Cr–W steel under gigacycle fatigue

Axial loading test was performed to investigate the influence of case-carburizing and micro-defect on competing failure behaviors of Ni–Cr–W Steel under gigacycle fatigue. The interior failures induced from inclusion and microstructural inhomogeneity become the predominant failure mode in the life regime beyond 10⁵ cycles. The case-carburizing has no effect on the fatigue strength with interior failure. Compared with the lower limit values of experimental S–N data, the predicted results by using GP distribution is relatively suitable. From the viewpoint of reliability, the modeling method of interior S–N curve with the maximum defect size at a given probability is satisfactory.